Agile BioFoundry y Lygos generarán una base de datos multiómicos para mejorar la producción de ácido malónico biobasado

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Tipo de entrada: NOTICIA BREVE.

Lygos, Inc. ha anunciado que está trabajando con la Agile BioFoundry (ABF) de la Oficina de Tecnologías de Bioenergía del Departamento de Energía de EEUU para generar el mayor conjunto de datos multiómicos para guiar el desarrollo de ácidos orgánicos.
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Figura 1. Agile BioFoundry y Lygos generarán una base de datos multiómicos para mejorar la producción de ácido malónico biobasado

En el transcurso del proyecto, los científicos producirán más de 500.000 puntos de datos a partir de una serie de experimentos. ABF ahora está utilizando sus redes neuronales artificiales para entrenar algoritmos de aprendizaje automático y proporcionar recomendaciones prácticas para ayudar a optimizar el rendimiento de la cepa, aumentar la eficiencia operativa y mejorar la producción de ácido malónico.

Juntos, Lygos y ABF tienen como objetivo demostrar un ciclo de ingeniería de alto rendimiento que incorpora el análisis multiómico y el aprendizaje automático. El proyecto aprovecha la experiencia de Lygos en el diseño, construcción y cultivo de sus cepas de levadura de ácido orgánico, así como su vía para la biosíntesis de ácido malónico. El análisis multiómico se realiza en el Laboratorio Nacional Lawrence Berkeley, el Laboratorio Nacional del Noroeste del Pacífico y los Laboratorios Nacionales Sandia. Los equipos planean poner el flujo de trabajo y el conjunto de datos a disposición del público a finales de este año.

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